Hb Palmerston North beta23(B5)Val->Phe
CONTACT Internal
HEMATOLOGY Erythrocytosis in the heterozygote
ELECTROPHORESIS No separation of Hb X and Hb A at alkaline pH; Hb X moves approximately like Hb F in IEF
STRUCTURE STUDIES Tryptic digestion; reversed phase HPLC; amino acid analysis; Dansyl-Edman degradation
DNA ANALYSES Not reported; presumed mutation GTT->TTT at codon 23
FUNCTION STUDIES Increased oxygen affinity; normal cooperativity
STABILITY Slightly unstable
OCCURRENCE Found in a 73-year-old female in New Zealand
OTHER INFORMATION Quantity in the heterozygote 40%
1. Brennan, S.O., Williamson, D., Whisson, M.E., and Carrell, R.W.: Hemoglobin, 6:569, 1982.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.