Hb Okazaki beta93(F9)Cys->Arg
CONTACT Internal
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves slower than Hb A; excellent separation by IEF
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation TGT->CGT at codon 93
FUNCTION STUDIES Increased oxygen affinity; Bohr effect slightly decreased
OCCURRENCE Found in a healthy, 45-year-old Japanese male
OTHER INFORMATION Quantity in the heterozygote 40-41%
1. Harano, K., Harano, T., Shibata, S., Ueda, S., Mori, H., and Seki, M.: FEBS Lett., 173:45, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.