Hb N-Seattle | beta61(E5)Lys->Glu |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate readily at alkaline pH (Hb X moves faster than Hb A) but not at acidic pH | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting and cation exchange chromatography; amino acid analysis; leucine amino peptidase; Edman degradation | ||
DNA ANALYSES | Not reported; presumed mutation AAG->GAG at codon 61 | ||
FUNCTION STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Black male who was a blood donor | ||
OTHER INFORMATION | Quantity in the heterozygote ~50% |
REFERENCES | |||
1. | Jones, R.T., Brimhall, B., Huehns, E.R., and Motulsky, A.G.: Biochim. Biophys. Acta, 154:278, 1968. |