Hb Moscva beta24(B6)Gly->Asp
CONTACT Internal; close contact with the E helix
HEMATOLOGY Hemolytic anemia with reticulocytosis in the heterozygote
ELECTROPHORESIS Hb X and Hb A can be separated at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; fingerprinting; amino acid analysis; thermolysin digestion; sequencing
DNA ANALYSES Not reported; presumed mutation GGT->GAT at codon 24
FUNCTION STUDIES Slightly decreased oxygen affinity; small change in Bohr effect and cooperativity
OCCURRENCE Found in a few members of a Russian family
OTHER INFORMATION Quantity in the heterozygote not determined
1. Idelson, L.I., Didkowsky, N.A., Casey, R., Lorkin, P.A., and Lehmann, H.: Nature, 249:768, 1974.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.