Hb Moriguchi beta97(FG4)His->Tyr
CONTACT External; alpha1beta2 contact
HEMATOLOGY Normal in the heterozygote; no erythrocytosis
ELECTROPHORESIS Hb X and Hb A separate by IEF; no separation by standard techniques
CHROMATOGRAPHY Hb X and Hb A separate by anion exchange HPLC; the betaX and betaA chains separate by CM-cellulose chromatography
STRUCTURE STUDIES Tryptic digestion of the AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation CAC->TAC at codon 97
FUNCTION STUDIES Slightly increased oxygen affinity; Bohr effect nearly normal
OCCURRENCE Found in a diabetic Japanese female and her 27-year-old son
OTHER INFORMATION Quantity in the heterozygote ~50%
1. Ohba, Y., Imai, K., Kumada, I., Ohsawa, A., and Miyaji, T.: Hemoglobin, 13:367, 1989.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.