Hb Minneapolis-Laos beta118(GH1)Phe->Tyr
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS IEF revealed an extra band with a mobility like Hb F
CHROMATOGRAPHY Hb X and Hb A can be separated on a DEAE-cellulose or a DEAE-Sephadex column
STRUCTURE STUDIES After aminoethylation, the betaX was digested with trypsin and the resulting fragments separated by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation TTT->TAT at codon 118
OCCURRENCE Found in a 27-year-old Laotian male and a 1-year-old Cambodian male and his mother
OTHER INFORMATION Quantity in the heterozygote ~45%
1. Hedlund, B., Paine, S., Smith, C.M., II, Raines, J., Morrison, W.T., and Adams, J., III: Hemoglobin, 8:75, 1984.
2. Kleman, K., Lubin, B., Kutlar, A., Wilson, J.B., Webber, B.B., and Huisman, T.H.J.: Hemoglobin, 11:401, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.