Hb K-Ibadan beta46(CD5)Gly->Glu
         
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves faster than Hb A at alkaline pH; no separation at acidic pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; fingerprinting or reversed phase HPLC for peptide separation; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GGG->GAG at codon 46
FUNCTION STUDIES Not reported
STABILITY Normal
OCCURRENCE Found in an African Yoruba adolescent and in an Italian family
OTHER INFORMATION Quantity in the heterozygote 28-33%
       
REFERENCES
1. Allan, N., Beale, D., Irvine, D., and Lehmann, H.: Nature, 208:658, 1965.
2. Castagnola, M., Cassiano, L., Rossetti, D.V., Marucci, L., Ferro, A., Scarano, C., Monaco, M., and Celozzi, A.M.: Hemoglobin, 14:647, 1990.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.