Hb J-Auckland beta25(B7)Gly->Asp
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate well at alkaline pH; Hb X moves faster than Hb A
CHROMATOGRAPHY Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE STUDIES Tryptic digestion; fingerprinting; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GGT->GAT at codon 25
FUNCTION STUDIES Decreased oxygen affinity
STABILITY Mildly unstable
OCCURRENCE Found in a family of Scandinavian and Scottish descent
OTHER INFORMATION Quantity in heterozygotes 40-50%
1. Williamson, D., Wells, R.M.G., Anderson, R., and Matthews, J.: Hemoglobin, 11: 221, 1987.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.