Hb Iowa beta119(GH2)Gly->Ala
CONTACT External; alpha1beta1 contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate by IEF; Hb X has the position near Hb F
CHROMATOGRAPHY No separation of Hb X and Hb A by cation exchange HPLC; the betaX and betaA chains separate by reversed phase HPLC (elution order: betaA, betaX, alpha)
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GGC->GCC at codon 119
OCCURRENCE Found in a 9-month-old infant and her mother
OTHER INFORMATION The proband was also heterozygous for Hb S
1. Plaseska, D., de Alarcon, P.A., McMillan, S., Walbrecht, M., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 14:432, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.