Hb Hikari beta61(E5)Lys->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X has a mobility like Hb J
CHROMATOGRAPHY Hb X and Hb A can be separated by different types of cation or anion exchange HPLC
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; pronase digestion
DNA ANALYSES Not reported; presumed mutation AAG->AAC or AAT at codon 61
OCCURRENCE Found in a few Japanese families
OTHER INFORMATION Quantity in the heterozygote ~45%
1. Shibata, S., Miyaji, T., Iuchi, I., Ueda, S., and Takeda, I.: Clin. Chim. Acta, 10: 101, 1964.
2. Nakatsuji, T., Miwa, S., Hattori, Y., Ohba, Y., Miyaji, T., Miyata, H., Shinohara, T., and Matsui, Y.: Hemoglobin, 5:487, 1981.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.