Hb G-Makassar beta6(A3)Glu->Ala
         
CONTACT External
HEMATOLOGY Presumed normal in the heterozygote
ELECTROPHORESIS Hb X moves to position of Hb S on starch gel at alkaline pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; fingerprinting; cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAG->GCG at codon 6
FUNCTION STUDIES Not reported
STABILITY Normal
OCCURRENCE Found in an Indonesian family from Southwest Sulawesi
OTHER INFORMATION Quantity in the heterozygote ~45%; no sickling reported
       
REFERENCES
1. Blackwell, R.Q., Oemijati, S., Pribadi, W., Weng, M-I., and Liu, C-S.: Biochim. Biophys. Acta, 214:396, 1970.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.