Hb G-Galveston beta43(CD2)Glu->Ala
ALSO KNOWN AS G-Port Arthur; G-Texas
CONTACT External
HEMATOLOGY Normal in heterozygotes
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH where Hb G is slightly faster than Hb S, and at acidic pH
STRUCTURE STUDIES Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAG->GCG at codon 43
STABILITY Not reported
OCCURRENCE Found in a few Black families, including a homozygote; a father and nine children; a mother and five children, and a Black male with a compound heterozygosity for Hb G and Hb S
OTHER INFORMATION Quantity in heterozygotes 50%; the homozygote is healthy
1. Edington, G.M., Lehmann, H., and Schneider, R.G.: Nature, 175:850, 1955.
2. Bowman, B.H., Moreland, H., and Schneider, R.G.: Nature, 193:1298, 1960.
3. McCurdy, P.R., Lorkin, P.A., Casey, R., Lehmann, H., Uddin, D.E., and Dickson, L.G.: Am. J. Med., 57:665, 1974.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.