Hb D-Iran beta22(B4)Glu->Gln
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A readily separate at alkaline pH; excellent separation by IEF; Hb X moves about as Hb S
CHROMATOGRAPHY Hb X and Hb A can be separated by cation and anion exchange HPLC
STRUCTURE STUDIES Proteolytic digests; fingerprinting; reversed phase HPLC; amino acid analysis; sequencing by Edman degradation
DNA ANALYSES Not reported; presumed mutation GAA->CAA at codon 22
OCCURRENCE Found in Iranian and Pakistani families; a Jamaican Black, and several families in Northern Calabria, Italy
OTHER INFORMATION Quantity in the heterozygote 36-45%; observed in combination with Hb S and with beta-thal
1. Rahbar, S.: Br. J. Haematol., 24:31, 1973.
2. Rohe, R.A., Sharma, V., and Ranney, H.M.: Blood, 42:455, 1973.
3. De Marco, E.V., Crescibene, L., Bagala, A., Brancati, C., Qualtieri, A., and Bria, M.: Hemoglobin, 18:65, 1994.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.