Hb Cook beta132(H10)Lys->Thr
         
CONTACT External; near central cavity
HEMATOLOGY About normal in the heterozygote
ELECTROPHORESIS Hb X is slightly faster than Hb A at alkaline pH; Hb X moves like Hb F at acidic pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Not reported
DNA ANALYSES An AAA->ACA mutation at codon 132
FUNCTION STUDIES Not reported
STABILITY Unstable
OCCURRENCE Found in a 28-year-old Thai female
OTHER INFORMATION Quantity in the heterozygote ~55%
       
REFERENCES
1. Hutt, P.J., Griffin, T., Fairbanks, V., Hoyer, J., and Thibodeau, S.: Blood, 86: 649a (Suppl. 1), 1995.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.