Hb Cocody beta21(B3)Asp->Asn
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH (Hb X moves like Hb S); excellent separation on IEF
CHROMATOGRAPHY Hb X and Hb A can be separated by cation exchange HPLC; the betaA and betaX chains separate completely by reversed phase HPLC
STRUCTURE STUDIES Proteolytic digestion; reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->AAT at codon 21
OCCURRENCE Found in a family from the Ivory Coast and in a Japanese family
OTHER INFORMATION Quantity in the heterozygote ~44%
1. Boissel, J.P., Wajcman, H., Fabritius, H., Cabannes, R., and Labie, D.: Biochim. Biophys. Acta, 670:203, 1981.
2. Ohba, Y., Hattori, Y., Ami, M., Yagami, H., Miyaji, T., and Tani, Y.: Hemoglobin, 14:109, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.