Hb Camden beta131(H9)Gln->Glu
ALSO KNOWN AS Tokuchi; Motown
CONTACT Internal; alpha1beta1 contact
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves faster than Hb A; at acidic pH Hb X moves close to Hb F
CHROMATOGRAPHY Hb X and Hb A separate by cation and anion exchange chromatography
STRUCTURE STUDIES Tryptic digestion of AE-betaX chain; separation of peptides by fingerprinting or cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation CAG->GAG at codon 131
FUNCTION STUDIES Normal oxygen affinity
OCCURRENCE Found in several Black families and in a Japanese family
OTHER INFORMATION Quantity in the heterozygote 35-46%; found in combination with Hb S and with alpha-thal
1. Wade-Cohen, P.T., Yates, A., Bellingham, A.J., and Huehns, E.R.: Nature, 243: 467, 1973.
2. Hubbard, M., Wilson, J.B., Wrightstone, R.N., Efremov, G.D., and Huisman, T.H.J.: Acta Haematol., 54:53, 1975.
3. Ohba, Y., Miyaji, T., Matsuoka, M., Ueda, S., Iuchi, I., and Shibata, S.: Acta Haematol. Jap., 38:1, 1975.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.