Hb Agenogi beta90(F6)Glu->Lys
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X and Hb A separate at alkaline pH; Hb X moves close to Hb A2
CHROMATOGRAPHY Hb X elutes behind Hb A2 from a cation exchange HPLC column
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAG->AAG at codon 90
FUNCTION STUDIES Slightly reduced oxygen affinity; normal Bohr effect and cooperativity
STABILITY Slightly reduced
OCCURRENCE Found in a Japanese family, a Black American family, and a Hungarian family
OTHER INFORMATION Quantity in the heterozygote 36.5-40.5%; occurred in association with a betao-thal
1. Miyaji, T., Suzuki, H., Ohba, Y., and Shibata, S.: Clin. Chim. Acta, 14:624, 1966.
2. Imai, K., Morimoto, H., Kotani, M., Shibata, S., Miyaji, T., and Matsutomo, K.: Biochim. Biophys. Acta, 200:197, 1970.
3. Castro, O., Winter, W.P., Doan, R.J., Lee, C.K., and Rucknagel, D.L.: Clin. Res., 24:630A, 1976.
4. Corso, D., Cognata, B., Ciaccio, C., Piazza, T., Dibenedetto, S.P., Samperi, P., Russo Mancuso, G., and Schiliro, G.: Hemoglobin, 14:549, 1990.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.