Hb Jackson	alpha127(H10)Lys->Asn

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J-Baltimore at alkaline pH
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex or DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting or cation exchange chromatography; chymotrypsin; amino acid analysis; sequen-cing; carboxypeptidase C; aminopeptidase M; chymotryptic digestion of the oxidized core
DNA ANALYSES		Not reported; presumed mutation AAG->AAT or AAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a few Black families from the Southeastern USA
OTHER INFORMATION		Quantity in the heterozygote 20-25%

REFERENCES
1.		Moo-Penn, W.F., Bechtel, K.C., Johnson, M.H., Jue, D.L., Holland, S., Huff, C., and Schmidt, R.M.: Am. J. Clin. Pathol., 66:453, 1976.
2.		Lam, H., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: J. Chromatogr., 269: 119, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.