Hb J-Medellin alpha22(B3)Gly->Asp
         
CONTACT External
HEMATOLOGY Not reported
ELECTROPHORESIS Hb X moves faster than Hb J at alkaline pH
CHROMATOGRAPHY Not reported
STRUCTURE STUDIES Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GGC->GAC; alpha2 or alpha1
FUNCTIONAL STUDIES Not reported
STABILITY Not reported
OCCURRENCE Found in two families from Colombia
OTHER INFORMATION Quantity in heterozygotes 20%
       
REFERENCES
1. Gottlieb, A.J., Restrepo, A., and Itano, H.A., Fed. Proc., 23:172, 1964.


This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.