Hb J-Anatolia | alpha61(E10)Lys->Thr |
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CONTACT | External | ||
HEMATOLOGY | Probably normal in the heterozygote | ||
ELECTROPHORESIS | Hb X separates from Hb A at alkaline pH; starch gel showed a fast-moving band in the region of Hb J and a fast extra Hb A2 band | ||
CHROMATOGRAPHY | Hb X can be separated from Hb A by anion exchange HPLC | ||
STRUCTURE STUDIES | Tryptic peptides were isolated by reversed phase HPLC; the alphaXT-9 carried an extra threonine at the amino terminus; amino acid analysis; sequencing | ||
DNA ANALYSES | Mutation in the alpha2 gene: AAG->ACG at codon 61 | ||
FUNCTIONAL STUDIES | Normal oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Turkish woman | ||
OTHER INFORMATION | Quantity in the heterozygote 27-28% |
REFERENCES | |||
1. | Giardano, P.C., Fodde, R., Amons, R., Ploem, J.E., and Bernini, L.F.: Hemoglobin, 14:119, 1990. |