Hb Fukutomi | alpha126(H9)Asp->Val |
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CONTACT | alpha1beta1 contact | ||
HEMATOLOGY | Slight erythrocytosis in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A are best separated by IEF | ||
CHROMATOGRAPHY | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of alphaX chain; separation of peptides by reversed phase HPLC; sequence analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAC->GTC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; increased resistance to oxidation | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a 52-year-old Japanese male | ||
OTHER INFORMATION | Quantity in the heterozygote 24% |
REFERENCES | |||
1. | Hidaka, K., Iuchi, I., Kobayashi, T., Katoh, K., and Yaguchi, K.: Hemoglobin, 14: 499, 1990. |