Hb Dunn	alpha6(A4)Asp->Asn

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves like Hb F on cellulose acetate (pH 8.4); it moves between Hb A and Hb S on citrate agar (pH 6.0)
CHROMATOGRAPHY		Hb X separates from Hb A by DEAE-Sephadex or DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis; carboxypeptidase; sequencing
DNA ANALYSES		Not reported; presumed mutation GAC->AAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity; Bohr and 2,3-DPG effects normal
STABILITY		Normal
OCCURRENCE		In Black, Indian, and Moroccan families
OTHER INFORMATION		Quantity in heterozygotes 11.6%

REFERENCES
1.		Jue, D.L., Johnson, M.H., Patchen, L.C., and Moo-Penn, W.F., Hemoglobin, 3: 137, 1979.
2.		Charache, S., Brimhall, B., and Zaatari, G., Am. J. Hematol., 9:151, 1980.
3.		Nakatsuji, T., Webber, B.B., Johnson, S.E.N., and Huisman, T.H.J.: Hemoglobin, 7:597, 1983.
4.		Baklouti, F., Francina, A., Dorléac, E., Baudin-Chich, V., Gombaud-Saintonge, G., Plauchu, H., Wajcman, H., Delaunay, J., and Godet, J.: Am. J. Hematol., 27: 253, 1988.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.