Hb Dagestan	alpha60(E9)Lys->Glu

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; the variant is fast-moving (position of Hb I on starch gel)
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation AAG->GAG; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a female from Dagestan
OTHER INFORMATION		Quantity in the heterozygote estimated at 30%

REFERENCES
1.		Spivak, V.A., Molchanova, T.P., Ermakov, N.V., Tokarev, Yu.N., Martinez, G., Szelenyi, Ju., Horanyi, M., Foldi, J., Hollan, S., Kazieva, H., and Shamov, I.A.: Hemoglobin, 5:133, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.