Hb Cordele | alpha47(CE5)Asp->Ala |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves slower than Hb S at alkaline pH (cellulose acetate) | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE-cellulose chromatography | ||
STRUCTURE STUDIES | The tryptic peptides were separated by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAC->GCC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal oxygen affinity | ||
STABILITY | Mildly unstable | ||
OCCURRENCE | Found in a Black family | ||
OTHER INFORMATION | Quantity in heterozygotes 21-23% |
REFERENCES | |||
1. | Nakatsuji, T., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:37, 1984. |