Hb Cordele alpha47(CE5)Asp->Ala
CONTACT External
HEMATOLOGY Normal in the heterozygote
ELECTROPHORESIS Hb X moves slower than Hb S at alkaline pH (cellulose acetate)
CHROMATOGRAPHY Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES The tryptic peptides were separated by reversed phase HPLC; amino acid analysis
DNA ANALYSES Not reported; presumed mutation GAC->GCC; alpha2 or alpha1
FUNCTIONAL STUDIES Normal oxygen affinity
STABILITY Mildly unstable
OCCURRENCE Found in a Black family
OTHER INFORMATION Quantity in heterozygotes 21-23%
1. Nakatsuji, T., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:37, 1984.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.