Hb Chiapas	alpha114(GH2)Pro->Arg

CONTACT		alpha1beta1 contact
HEMATOLOGY		Not reported
ELECTROPHORESIS		Hb X is slightly faster than Hb S at alkaline pH
CHROMATOGRAPHY		Hb X was isolated on an Amberlite IRC-50 column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CCC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a Mexican family
OTHER INFORMATION		Quantity in the heterozygote ~25%

REFERENCES
1.		Jones, R.T., Brimhall, B., and Lisker, R.: Biochim. Biophys. Acta, 154:488, 1968.
2.		Ibarra, B., Franco-Gamboa, E., Ramirez, M.L., Cantu, J.M., Wilson, J.B., Lam, H., and Huisman, T.H.J.: Hemoglobin, 5:605, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.