Hb Anamosa	alpha111(G18)Ala->Val

CONTACT		alpha1beta1 contact
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X was detected by IEF where it focused just ahead of Hb A
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation exchange HPLC
STRUCTURE STUDIES		Identification by DNA analysis only
DNA ANALYSES		A GCC->GTC mutation at codon 111 of the alpha2 gene
FUNCTIONAL STUDIES		Not reported
STABILITY		Stable
OCCURRENCE		Discovered in a Caucasian baby and his father
OTHER INFORMATION		Quantity in the heterozygote ~20%

REFERENCES
1.		Kazanetz, E.G., Leonova, J.Ye., Wilson, J.B., McMillan, S.K., Walbrecht, M., de Pablos Gallego, J.Ma., and Huisman, T.H.J.: Hemoglobin, 19:1, 1995.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.