Hb F-Xin-Su | Agamma73(E17)Asp->His |
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ELECTROPHORESIS | Hb FX moves between Hb A and Hb S at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX can readily be isolated by DEAE-cellulose chromatography | ||
CHAIN SEPARATION | AgammaX = 12.7%; AgammaT = 14.9%; Ggamma = 72.4% | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by fingerprinting or reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAT->CAT at codon 73 | ||
NOTES | Found in a Chinese baby of the Han nationality; the baby was also heterozygous for the AgammaT chain |
REFERENCES | |||
1. | Ma, M., Hu, H., Kutlar, F., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 11:473, 1987. |