Hb F-Victoria Jubilee | Agamma80(EF4)Asp->Tyr |
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ELECTROPHORESIS | Hb FX moves slightly slower than Hb S at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes between Hb A and Hb F from a DEAE-cellulose column | ||
CHAIN SEPARATION | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of AE-gammaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAT->TAT at codon 80 | ||
NOTES | Found in a Black newborn; quantity in the heterozygote 7% of total Hb F |
REFERENCES | |||
1. | Ahern, A., Holder, W., Ahern, V., Serjeant, G.R., Serjeant, B.E., Forbes, M., Brimhall, B., and Jones, R.T.: Biochim. Biophys. Acta, 393:188, 1975. |