Hb F-Victoria Jubilee Agamma80(EF4)Asp->Tyr
ELECTROPHORESIS Hb FX moves slightly slower than Hb S at alkaline pH
IEF Not reported
CHROMATOGRAPHY Hb FX elutes between Hb A and Hb F from a DEAE-cellulose column
STRUCTURE STUDIES Tryptic digestion of AE-gammaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->TAT at codon 80
NOTES Found in a Black newborn; quantity in the heterozygote 7% of total Hb F
1. Ahern, A., Holder, W., Ahern, V., Serjeant, G.R., Serjeant, B.E., Forbes, M., Brimhall, B., and Jones, R.T.: Biochim. Biophys. Acta, 393:188, 1975.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.