Hb F-Texas-I | Agamma5(A2)Glu->Lys |
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ELECTROPHORESIS | Hb FX moves slower than Hb C at alkaline pH | ||
IEF | About the same | ||
CHROMATOGRAPHY | Hb FX can be isolated by cation and anion exchange HPLC | ||
CHAIN SEPARATION | No data reported | ||
STRUCTURE STUDIES | Tryptic digestion of Hb FX; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->AAG at codon 5 | ||
NOTES | Found in several Black babies; quantity in heterozygotes ~12%; the gamma-Texas-I chain is considerably acetylated (three time more than the normal gamma chain) |
REFERENCES | |||
1. | Jenkins, G.C., Beale, D., Black, A.J., Huntsman, G.R., and Lehmann, H.: Br. J. Haematol., 13:252, 1967. | ||
2. | Ahern, E.J., Wiltshire, B.G., and Lehmann, H.; Biochim. Biophys. Acta, 271:61, 1972. | ||
3. | Keitt, A.S. and Jones, R.T.: Am. J. Hematol., 28:47, 1988. |