Hb F-Dammam | Agamma79(EF3)Asp->Asn |
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ELECTROPHORESIS | Hb FX moves between Hb S and Hb C | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes between Hb A2 and Hb A on DEAE-cellulose; no separation from Hb A in cation exchange HPLC | ||
CHAIN SEPARATION | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAT->AAT at codon 79 | ||
NOTES | Found in an Arabian newborn who is also heterozygous for the AgammaT chain; Hb FX 6.9% of total Hb or 13.1% of total Hb F |
REFERENCES | |||
1. | Al-Awamy, B.H., Niazi, G.A., Al-Mouzan, M.I., Wilson, J.B., Chen, S.S., Webber, B.B., and Huisman, T.H.J.: 9:171, 1985. |