Hb F-Dammam Agamma79(EF3)Asp->Asn
ELECTROPHORESIS Hb FX moves between Hb S and Hb C
IEF Not reported
CHROMATOGRAPHY Hb FX elutes between Hb A2 and Hb A on DEAE-cellulose; no separation from Hb A in cation exchange HPLC
STRUCTURE STUDIES Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis; sequencing
DNA ANALYSES Not reported; presumed mutation GAT->AAT at codon 79
NOTES Found in an Arabian newborn who is also heterozygous for the AgammaT chain; Hb FX 6.9% of total Hb or 13.1% of total Hb F
1. Al-Awamy, B.H., Niazi, G.A., Al-Mouzan, M.I., Wilson, J.B., Chen, S.S., Webber, B.B., and Huisman, T.H.J.: 9:171, 1985.

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.