A Database of Human Hemoglobin Variants and Thalassemias
This is a relational database of information about hemoglobin variants and
mutations that cause thalassemia. The initial data came from
authored by Prof. Titus H.J. Huisman, Mrs. Marianne F.H. Carver,
Dr. Erol Baysal, and Prof. Georgi D. Efremov.
This information was converted to a database, and now new entries are added
and old entries are corrected by our curators, Dr. Henri Wajcman,
and Dr. George Patrinos.
HbVar results from a collaboration among several investigators
at Penn State University (USA), INSERM Creteil (France), and Boston
University Medical Center (USA). Visit our query
page or summary page to see the types of information available.
To access summaries of the categories of the mutations, click here.
Summaries of mutation categories
has counts of the results for common queries and buttons to link to them.
Most recent update
Difference in mass chart
XPRbase has experimental protocols
Help with numbers
Help with HGVS nomenclature
Frequently Asked Questions
How to contact us
- Number of users from January 27, 2000 to June 5, 2013
- Query page 71,633
Summary page 40,582
Html syllabus 208,998
Databases of Human Hemoglobin Variants and Other Resources at the
Globin Gene Server.
HbVar: A relational database of human hemoglobin variants and thalassemia mutations at the globin gene server:
Improvements in the HbVar database of human hemoglobin variants and thalassemia
mutations for population and sequence variation studies.
HbVar Database of Human Hemoglobin Variants and Thalassemia Mutations:
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.
table (.xls) and
SeqView, a Sequence Visualisation Program
PhenCode - connects data from LSDBs (including HbVar) to genome browsers.
LOVD version of the Globin Gene Server
(this includes some genes not in HbVar)
Most of this material is derived from the books
A Syllabus of Human Hemoglobin Variants (Second Edition, 1998)
by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov,
A Syllabus of Thalassemia Mutations (1997)
by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal,
both published by
The Sickle Cell Anemia Foundation in Augusta, GA, USA.
Obtaining a printed copy
Citing this resource*
*Patrinos, G.P., B. Giardine, C. Riemer, W. Miller, D.H.K. Chui, N.P.
Anagnou, H. Wajcman, and R.C. Hardison (2004)
Improvements in the
HbVar database of human hemoglobin variants and thalassemia mutations
for population and sequence variation studies. Nucl. Acids Res . 32
Database issue: D537-541.